Hemibagrus wyckii is a species of catfish (order Siluriformes) of the family Bagridae. It is occasionally called the crystal-eyed catfish.

This species originates in Asia from Thailand to Indonesia. It is known from the Mekong and Chao Phraya drainages in central Indochina. It is also known from the Batang Hari and Musi river drainages in Sumatra, the Pahang river drainage in Peninsular Malaysia, the Citarum drainage in Java, and the Baram, Rejang, Kapuas, and Barito river drainages in Borneo.

H. wyckii are black with a few white markings on the caudal and dorsal fins, and the eyes are sky blue. They reach about 71 centimetres (28 in) SL. The head is extremely depressed and broad. The caudal fin is dark grey. The dorsal fin spine has 10–12 serrations on the posterior edge.

H. wyckii bears a resemblance to H. wyckioides, however H. wyckioides lacks serrations on the dorsal fin spine, has a shorter dorsal fin base, and shorter maxillary barbels.